The CaixaForum is located in the former fàbrica tèxtil Casaramona (Casaramona textile factory) in Montjuïc, which specialised in the manufacture of blankets and towels. This building designed by Josep Puig is an exceptional example of Catalan industrial "modernista" architecture of the early twentieth century. It comprises a set of single-story buildings, a horizontal construction to facilitate the transfer of goods through a system of internal streets that at the same time also served as a firewall.

The building was acquired by Obra Social "la Caixa" in 1963. In 2002, after a restoration and expansion project, it became a cultural centre for Barcelona. It offers social, cultural and educational programming that includes ongoing events such as lectures, film screenings, performances, concerts and family activities.

In addition, a quarter of the total 12,000 m2 building is occupied by ancient, modern and contemporary art exhibitions. It also has an outstanding collection of artistic and documentary art media.